Genotype assays and third-line ART in resource-limited settings

Genotype assays and third-line ART in resource-limited settings: a simulation and cost-effectiveness analysis of a planned clinical trial.

OBJECTIVES To project the clinical and economic outcomes of a genotype assay for selection of third-line antiretroviral therapy (ART) in resource-limited settings, as per the planned international A5288 trial (MULTI-OCTAVE). METHODS We used the Cost-effectiveness of Preventing AIDS Complications (CEPAC)-International Model to compare three strategies for patients who have failed second-line A...

Improving first-line antiretroviral therapy in resource-limited settings.

PURPOSE OF REVIEW Access to first-line antiretroviral therapy in resource-limited settings has increased rapidly in the last 5 years. Newer medicines with greater potency and better safety profiles open the possibility for improving first-line antiretroviral therapy for developing countries. RECENT FINDINGS Several medicines offer the potential to improve the simplicity, safety and efficacy o...

Resuscitation in resource-limited settings.

Intrapartum-related hypoxia leading to deaths and disabilities continues to be a global challenge, especially in resource-limited settings. Primary prevention during labour is likely to have a significant impact, but secondary prevention with focus on immediate basic stabilization at birth can effectively reduce a large proportion of these adverse outcomes as demonstrated in the resource-rich s...

HIV RNA and genotype in resource-limited settings: can we do better?

World Health Organization (WHO) recommendations to scale up antiretroviral treatment (ART) have impacted mortality, morbidity, and potentially the transmission of human immunodeficiency virus (HIV) [1, 2]. Because suppression of virus replication reduces both disease progression and transmission, virologic failure provides a surrogate biologic marker for the effectiveness of treatment. Measurem...

Viral load testing in resource-limited settings.